The F-22 Raptor is a 5th generation stealth fighter operated by the USAF.
In Syphon Filter 2
F-22s appear in Syphon Filter 2 They are operated by Agency fighter pilots. A pair of F-22s are scrambled out of McKenzie AFB in Colorado to intercept a CBDC C-130 carrying a CBDC team while enroute to Arizona.
One F-22 can be seen landing on McKenzie AFB, showing an unknown logo as well as the emblem of the Air Combat Command. It also has a "NE" tail code. Aircraft with this particular tail code belong to Carrier Air Wing Two (CVW-2), a United States Navy aircraft carrier air wing based at Naval Air Station Lemoore. The air wing is attached to the aircraft carrier USS Carl Vinson (CVN-70).
One of the two pilots is subsequently shot by Dillon Morgan when he fails to stop the C-130's crew from escaping, prompting the other pilot to release nerve gas on the C-130 crash site. Lian Xing manages to sabotage an F-22 and kill its pilot before the Agency could deploy this lethal agent on Gabe Logan and the other surviving CBDC agents.