The F-22 Raptor is a 5th generation stealth fighter operated by the USAF.
In Syphon Filter
F-22s appear in Syphon Filter 2 They are operated by Agency fighter pilots. A pair of F-22s are scrambled out of McKenzie AFB in Colorado to intercept a CBDC C-130 while enroute to Arizona.
An F-22 Raptor
Lian Xing manages to sabotage an F-22 and kill it's pilot before the Agency could deploy poison gas on Gabe Logan and the other surviving CBDC agents.